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Original Article
March 6, 2026

Sex-related differences in femorotibial cartilage thickness: A matched pair analysis

Noël Spoelder, Tom D Turmezei, Dimitri A Kessler, James W Mackay, Simon C Mas...

Annals of Anatomy

Background: Women are more frequently affected by knee osteoarthritis (OA) than men. Differences in knee cartilage thickness have been proposed as an explanation, but it remains unclear whether these differences reflect true sex-specific variation or differences in body size. Clarifying this...

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Original Article
February 5, 2026

Exploratory analysis of the 2-year changes in knee cartilage thickness and transverse relaxation time (T2) in ACL-injured versus healthy participants

Herger S, Wirth W, Nüesch C, Bieri O, Egloff C, Eckstein F, Mündermann A

Osteoarthr Cartil Open

Objective: To investigate the 2-year changes in cartilage thickness and transverse relaxation time (T2) in magnetic resonance images (MRI) of ACL-injured (ACL_in) and uninjured contralateral knees (ACL_unin), compared to...

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AI-based Analysis Review
February 3, 2026

Advances in cartilage imaging techniques

Guermazi A, Eckstein F, Gold G, Hayashi D, Jarraya M, Kogan F, Li X, Link TM,...

Nat Rev Rheumatol

Articular cartilage is crucial for joint function; however, it has limited regenerative capacity when damaged, a hallmark of many rheumatic diseases. Non-invasive imaging is essential for early diagnosis, therapeutic monitoring and prognostication. MRI remains the reference standard, offering detailed assessment of both morphological and compositional cartilage changes. Technological...

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AI-based Analysis Review
January 15, 2026

Magnetic resonance imaging (MRI) transverse relaxation time (T2) for non-invasive assessment of cartilage composition

Eckstein F, Bangerter N, Wirth W.

Paracelsus Proceedings of Experimental Medicine

MRI has transformed medical imaging and research by enabling detailed 3D visualization of soft tissue anatomy. But it also provides insight into biophysical, histological, and mechanical properties via quantitative MRI relaxometry (qMRI). Cartilage transverse...

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AI-based Analysis Perspective
September 20, 2025

Multifaceted imaging strategies for clinical trials of knee osteoarthritis: a tightly interlinked value and precision chain

Felix Eckstein, Ali Mobasheri, Mikael P Boesen

Skeletal Radiology

Osteoarthritis is a debilitating, whole-organ disease that involves all osteoarticular tissues. No effective treatments have yet been approved by the regulatory agencies for modifying the natural history of this disease and its structural progression....

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Original Article
September 7, 2025

Magnetic resonance imaging biomarkers of knee osteoarthritis progression

Collins JE, Mesenbrink P, Jin R, Dam EB, Deveza LA, Eckstein F, Guermazi A, L...

ACR Open Rheumatol

Objective: The Foundation for the National Institutes of Health (FNIH) OA Biomarkers Consortium aims to identify, develop, and qualify biomarkers to support drug development in knee osteoarthritis (OA). The project's second phase, the PROGRESS OA study, aims to externally validate prognostic...

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Original Article
September 4, 2025

Fluctuation of bone marrow lesions and inflammatory MRI markers over 2 years and concurrent associations with quantitative cartilage loss

Frank W Roemer, Mylène P Jansen, Susanne Maschek, Simon C Mastbergen, Anne-Ka...

Cartilage

ObjectiveTo assess whether change of semiquantitatively magnetic resonance imaging (MRI)-defined bone marrow lesions (BMLs) and inflammatory markers is associated with change in quantitatively-assessed cartilage loss in the femorotibial...

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