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Publication Outlet: Osteoarthritis Cartilage

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Original Article
November 15, 2024

Anterior cruciate ligament injury and age affect knee cartilage T2 but not thickness

Simon Herger, Wolfgang Wirth, Felix Eckstein, Corina Nüesch, Christian Egloff...

Osteoarthritis Cartilage

Objective: To investigate the effect of unilateral anterior cruciate ligament (ACL) injury on cartilage thickness and composition, specifically laminar transverse relaxation time (T2) by magnetic resonance imaging (MRI), in younger and older participants and to compare within-person side differences in these...

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Trial Data Analysis
October 20, 2024

Is detection of disease-modifying osteoarthritis drug treatment more effective when performing cartilage morphometry without blinding to MR image acquisition order?

Felix Eckstein, Anna Wisser, Susanne Maschek, Wolfgang Wirth, Christoph Ladel...

Osteoarthritis Cartilage

Objective: We here explore whether observed treatment effects of a putative disease-modifying osteoarthritis drug (DMOAD) are greater when cartilage morphometry is performed with...

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Original Article
October 19, 2023

Association of quantitative measures of medial meniscal extrusion with structural and symptomatic knee osteoarthritis progression – data from the OAI FNIH biomarker study.

Kalpana Sharma, Felix Eckstein, Susanne Maschek, Melanie Roth, David J Hunter...

Osteoarthritis Cartilage

Objective: To study the association of quantitative medial meniscal position measures with radiographic and symptomatic knee osteoarthritis (OA) progression over 2-4 years....

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Trial Data Analysis
July 17, 2023

Evaluation of S201086/GLPG1972, an ADAMTS-5 inhibitor, for the treatment of knee osteoarthritis in ROCCELLA: a phase 2 randomized clinical trial.

T Schnitzer, M Pueyo, H Deckx, E van der Aar, K Bernard, S Hatch, M van der S...

Osteoarthritis Cartilage

Objective: To evaluate the efficacy and safety of the anti-catabolic ADAMTS-5 inhibitor S201086/GLPG1972 for the treatment of symptomatic knee osteoarthritis. Design: ROCCELLA (NCT03595618) was a randomized, double-blind, placebo-controlled,...

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Original Article
February 15, 2023

Test-retest precision and longitudinal cartilage thickness loss in the IMI-APPROACH cohort.

W Wirth, S Maschek, A C A Marijnissen, A Lalande, F J Blanco, F Berenbaum, L ...

Osteoarthritis Cartilage

Objective: To investigate the test-retest precision and to report the longitudinal change in cartilage thickness, the percentage of knees with progression and the predictive value of the machine-learning-estimated structural progression score (s-scor...

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Original Article
May 22, 2022

Association between osteoarthritis-related serum biochemical markers over 11 years and knee MRI-based imaging biomarkers in middle-aged adults.

A Singh, A Venn, L Blizzard, G Jones, J Burgess, V Parameswaran, F Cicuttini,...

Osteoarthritis Cartilage

Objective: To describe the associations between osteoarthritis (OA)-related biochemical markers (COMP, MMP-3, HA) and MRI-based imaging biomarkers in middle-aged adults over 10-13 years. Methods: Blood serum samples collected...

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Trial Data Analysis
February 20, 2021

Early anterior cruciate ligament reconstruction does not affect 5 year change in knee cartilage thickness: secondary analysis of a randomized clinical trial.

W Wirth, F Eckstein, A G Culvenor, M I Hudelmaier, L Stefan Lohmander, R B Fr...

Osteoarthritis Cartilage

Objective: To compare 5-year change in femorotibial cartilage thickness in 121 young, active adults with an acute anterior cruciate ligament (ACL) tear randomized to a strategy of structured...

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