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Publication Outlet: Osteoarthr Cartil Open

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Original Article
February 5, 2026

Exploratory analysis of the 2-year changes in knee cartilage thickness and transverse relaxation time (T2) in ACL-injured versus healthy participants

Herger S, Wirth W, Nüesch C, Bieri O, Egloff C, Eckstein F, Mündermann A

Osteoarthr Cartil Open

Objective: To investigate the 2-year changes in cartilage thickness and transverse relaxation time (T2) in magnetic resonance images (MRI) of ACL-injured (ACL_in) and uninjured contralateral knees (ACL_unin), compared to...

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AI-based Analysis Original Article
August 5, 2025

Comparison between coronal FLASH and sagittal double echo steady state MRI in detecting longitudinal cartilage thickness change by fully automated segmentation – data from the FNIH biomarker cohort

Eckstein F, Chaudhari AS, Hunter DJ, Wirth W

Osteoarthr Cartil Open

Objective: Artificial intelligence (AI-) based automated cartilage analysis demonstrated similar sensitivity to change and only slighty inferior differentiation between radiographic progressors and non-progressors...

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Original Article
August 4, 2025

Cartilage loss is greater in knees with virtual joint replacement status than in matched controls without

Eckstein F, Wirth W, Guermazi A, Roemer F, Nevitt M, Ladel C, Sharma L, Hunte...

Osteoarthr Cartil Open

Objective: We examined whether the trajectory of femorotibial cartilage loss differs between knees meeting a clinically defined virtual knee replacement (vKR) status based on patient-reported outcomes vs. those with low probability. Design: vKR cases (highest 10...

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Trial Data Analysis
August 18, 2024

Unbiased analysis of knee cartilage thickness change over three years after sprifermin vs. placebo treatment – a post-hoc analysis from the phase 2b FORWARD study.

Felix Eckstein, Susanne Maschek, Wolfgang Wirth, Christoph Ladel, Asger Reins...

Osteoarthr Cartil Open

Objective: Post-treatment cartilage morphometry in the FORWARD study was performed without blinding to MRI acquisition order, involving potential reader bias. Here we...

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Design Paper
July 24, 2024

The design of a sample rapid magnetic resonance imaging (MRI) acquisition protocol supporting assessment of multiple articular tissues and pathologies in knee osteoarthritis.

Felix Eckstein, Thula Cannon Walter-Rittel, Akshay S Chaudhari, Nicholas M Br...

Osteoarthr Cartil Open

Objective: This expert opinion paper proposes a design for a state-of-the-art magnetic resonance image (MRI) acquisition protocol for knee osteoarthritis clinical trials...

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Original Article
April 12, 2023

Which risk factors determine cartilage thickness and composition change in radiographically normal knees? – data from the Osteoarthritis Initiative.

F Eckstein, S Maschek, A Culvenor, L Sharma, F W Roemer, G N Duda, W Wirth

Osteoarthr Cartil Open

Objective: Therapy for osteoarthritis ideally aims at preserving structure before radiographic change occurs. This study tests: a) whether longitudinal deterioration in cartilage thickness and composition (transverse relaxation-time T2)...

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