Publication Outlet: JAMA

Effect of Intra-Articular sprifermin vs placebo on femorotibial joint cartilage thickness in patients with osteoarthritis: the FORWARD randomized clinical trial.

Marc C Hochberg, Ali Guermazi, Hans Guehring, Aida Aydemir, Stephen Wax, Patr...

JAMA

Importance: Sprifermin is under investigation as a disease-modifying osteoarthritis drug. Objective: To evaluate the effects of sprifermin on changes in total femorotibial...

Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial

Stephen P Messier، Shannon L Mihalko، Claudine Legault، Gary D Miller، Barbar...

JAMA

Importance: Knee osteoarthritis (OA), a common cause of chronic pain and disability, has biomechanical and inflammatory origins and is exacerbated by obesity. Objective: To...