Publication Outlet: Annals of the Rheumatic Diseases

Long-term structural and symptomatic effects of intra-articular sprifermin in patients with knee osteoarthritis: 5-year results from the FORWARD study.

Felix Eckstein, Marc C Hochberg, Hans Guehring, Flavie Moreau, Victor Ona, As...

Annals of the Rheumatic Diseases

Objective: The FORWARD (FGF-18 Osteoarthritis Randomized Trial with Administration of Repeated Doses) trial assessed efficacy and safety of the potential disease-modifying osteoarthritis drug (DMOAD) sprifermin in patients with...

Intra-articular sprifermin reduces cartilage loss in addition to increasing cartilage gain independent of location in the femorotibial joint: post-hoc analysis of a randomised, placebo-controlled phase II clinical trial.

Felix Eckstein, Jeffrey L Kraines, Aida Aydemir, Wolfgang Wirth, Susanne Masc...

Annals of the Rheumatic Diseases

Objectives: In the phase II FGF-18 Osteoarthritis Randomized Trial with Administration of Repeated Doses (FORWARD) study, sprifermin demonstrated cartilage modification in the...

Quantitative MRI measures of cartilage predict knee replacement: a case-control study from the Osteoarthritis Initiative.

Felix Eckstein, C Kent Kwoh, Robert M Boudreau, Zhijie Wang, Michael J Hannon...

Annals of the Rheumatic Diseases

Objective: Knee osteoarthritis commonly requires joint replacement, substantially reduces quality of life and increases healthcare utilisation and costs. This study aimed to identify whether quantitative measures of articular cartilage structure pred...

Tissue structure modification in knee osteoarthritis by use of joint distraction: an open 1-year pilot study.

Femke Intema, Peter M Van Roermund, Anne C A Marijnissen, Sebastian Cotofana,...

Annals of the Rheumatic Diseases

Background: Modification of joint tissue damage is challenging in late-stage osteoarthritis (OA). Few options are available for treating end-stage knee OA other than joint replacement. Objectives: To examine whether joint distraction can effectively ...