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Publication Category: Trial Data Analysis

High tibial osteotomy for medial compartment knee osteoarthritis: a randomized trial with parallel preference arm

By Chondrometrics-admin

Background: Medial opening wedge high tibial osteotomy (HTO) is a limb realignment surgery that aims to preserve joint structure and improve clinical outcomes by redistributing ambulatory loads on the knee among patients with knee osteoarthritis and varus alignment. Objective: To evaluate the efficacy of medial opening wedge HTO. Design: Single-center, open-label, assessor-blinded randomized trial with a parallel preference … Continued

Is detection of disease-modifying osteoarthritis drug treatment more effective when performing cartilage morphometry without blinding to MR image acquisition order?

By Chondrometrics-admin

Objective: We here explore whether observed treatment effects of a putative disease-modifying osteoarthritis drug (DMOAD) are greater when cartilage morphometry is performed with rather than without knowledge of magnetic resonance imaging (MRI) acquisition order (unblinded/blinded to time point). Methods: In the FORWARD (FGF-18 Osteoarthritis Randomized Controlled Trial with Administration of Repeated Doses) randomized controlled trial, 549 knee … Continued

Effects of neuromuscular control and strengthening exercises on MRI-measured thigh tissue composition and muscle properties in people with knee osteoarthritis – an exploratory secondary analysis from a randomized controlled trial.

By Chondrometrics-admin

Objective: To investigate the effects of adding strength training to neuromuscular control exercises on thigh tissue composition and muscle properties in people with radiographic-symptomatic knee osteoarthritis (KOA). Methods: In this exploratory sec…