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Publication Category: Perspective

Sex differences in cartilage anatomy, imaging & treatment response

Objective: To review findings on sex differences in cartilage anatomy, cartilage imaging, and treatment in osteoarthritis, based on an invited presentation held at the International Workshop of Osteoarthritis Imaging (IWOAI) 2025. Design: A non-systematic literature search (Pubmed) and consultations with experts. Additionally, comparative radiographic joint space width (JSW) and femorotibial cartilage thickness data were obtained … Continued

20 years of the international workshop on osteoarthritis imaging (IWOAI): From a small pre-alpine village to a global community

Introduction: The International Workshop on Osteoarthritis Imaging (IWOAI) was founded in 2007 to create a focused scientific forum dedicated to imaging (biomarkers) in osteoarthritis. In contrast to large international congresses, the workshop was conceived as a small and interactive meeting encouraging open discussion and interdisciplinary exchange among researchers from academia and industry. Perspective: Since its … Continued

Skeletal interfaces in health and disease – where two worlds interact: the Salzburg Leopoldina Symposium 2025 – bridging disciplines and perspectives

Introduction: The Leopoldina Symposium on “Skeletal Interfaces in Health and Disease” at Paracelsus Medical University (Salzburg, Austria) gathered an interdisciplinary community of young and experienced scientists, to explore how crossing disciplinary boundaries can generate new insights and methodologies. While research traditionally focuses on organ- or disease-specific questions, this symposium aimed to connect seemingly distant scientific fields … Continued

Multifaceted imaging strategies for clinical trials of knee osteoarthritis: a tightly interlinked value and precision chain

Osteoarthritis is a debilitating, whole-organ disease that involves all osteoarticular tissues. No effective treatments have yet been approved by the regulatory agencies for modifying the natural history of this disease and its structural progression. In this whitepaper, we will summarize concepts of “multi-faceted” (multi-contrast) magnetic resonance imaging (MRI), with a focus on its application in … Continued

Which endpoints should be applied in interventional trials? from single uni-dimensional assessment tailored to a drug’s mechanism of action to multi-component measures and multi-domain composites

Objective: A vast array of structural/imaging and clinical endpoints/outcomes are available today to osteoarthritis epidemiologists or trialists. Which assessments are best suited for which studies remains unsettled. When several assessments are available, these may be analyzed together (simultaneously or hierarchically), using statistical modeling and adjustment. Or, alternatively, they may be combined to form more complex multi-component … Continued