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Publication Category: Perspective

Skeletal interfaces in health and disease – where two worlds interact: the Salzburg Leopoldina Symposium 2025 – bridging disciplines and perspectives

By Chondrometrics-admin

Introduction: The Leopoldina Symposium on “Skeletal Interfaces in Health and Disease” at Paracelsus Medical University (Salzburg, Austria) gathered an interdisciplinary community of young and experienced scientists, to explore how crossing disciplinary boundaries can generate new insights and methodologies. While research traditionally focuses on organ- or disease-specific questions, this symposium aimed to connect seemingly distant scientific fields … Continued

Multifaceted imaging strategies for clinical trials of knee osteoarthritis: a tightly interlinked value and precision chain

By Chondrometrics-admin

Osteoarthritis is a debilitating, whole-organ disease that involves all osteoarticular tissues. No effective treatments have yet been approved by the regulatory agencies for modifying the natural history of this disease and its structural progression. In this whitepaper, we will summarize concepts of “multi-faceted” (multi-contrast) magnetic resonance imaging (MRI), with a focus on its application in … Continued

Which endpoints should be applied in interventional trials? from single uni-dimensional assessment tailored to a drug’s mechanism of action to multi-component measures and multi-domain composites

By Chondrometrics-admin

Objective: A vast array of structural/imaging and clinical endpoints/outcomes are available today to osteoarthritis epidemiologists or trialists. Which assessments are best suited for which studies remains unsettled. When several assessments are available, these may be analyzed together (simultaneously or hierarchically), using statistical modeling and adjustment. Or, alternatively, they may be combined to form more complex multi-component … Continued