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Chondrometrics
Chondrometrics

RESEARCH - ORIGINAL ARTICLES - CARTILAGE


> Method Development & Validation

> Application

Method Development & Validation


Wirth W, Maschek S, Eckstein F

Sex- and age-dependence of region- and layer-specific knee cartilage composition (spin-spin-relaxation time) in healthy reference subjects.

Annals of Anatomy  210: 1-8 (2017)


Wirth W, Maschek S, Roemer FW, Eckstein F

Layer-specific femorotibial cartilage T2 relaxation time in knees with and without early knee osteoarthritis:Data from the Osteoarthritis Initiative (OAI).

Scientific Reports 6:34202 (2016)

Huang C, Shan L, Charles C, Wirth W, Niethammer M, Zhu H
Diseased region detection of longitudinal knee magnetic resonance imaging data.
IEEE Transactions on Medical Imaging 34:1912-1914 (2015)

Wirth W, Eckstein F, Boeth H, Diederichs D, Hudelmaier M, Duda GN
Longitudinal analysis of MR spinespin relaxation times (T2) in medialfemorotibial cartilage of adolescent vs mature athletes: dependence of deep and superficial zone properties on sex and age.
Osteoarthritis and Cartilage 22:1554-1558 (2014)

Wirth W, Duryea J, Hellio Le Graverand MP, John MR, Nevitt M, Buck RJ, Eckstein F; for the OA Initiative Investigators Group.
Direct comparison of fixed flexion, radiography and MRI in knee osteoarthritis: responsiveness data from the Osteoarthritis Initiative.
Osteoarthritis and Cartilage 21:117-125 (2013)

Buck J, Dreher D, Eckstein F
Femoral cartilage thickness change distributions for subjects without signs, symptoms, or risk factors of knee osteoarthritis
Cartilage 3:305-313 (2012)

  • Eckstein F, Mc Culloch CE, Lynch JA, Nevitt M, Kwoh CK, Maschek S, Hudelmaier M, Sharma L, Wirth W; for the OA Initiative Investigators Group

    How do short-term rates of femorotibial cartilage change compare to long-term changes? Four year follow-up data from the osteoarthritis initiative.

    Osteoarthritis and Cartilage 20:1250-1257 (2012)

  • Schneider E, Nevitt M, McCulloch C, Cicuttini FM, Duryea J, Eckstein F, Tamez-Pena J

    Equivalence and precision of knee cartilage morphometry between different segmentation teams, cartilage regions, and MR acquisitions.

    Osteoarthritis and Cartilage 20:869-879(2012)

  • Hudelmaier M, Glaser C, Pfau C, Eckstein F
  • Comparison between different implementations of the 3D FLASH sequence for knee cartilage quantification.
    Magnetic Resonance Materials in Physics, Biology and Medicine 25:305-312 (2012)

  • Wirth W, Buck R, Nevitt M, Le Graverand MP, Benichou O, Dreher D, Davies RY, Lee JH, Picha K, Gimona A, Maschek S, Hudelmaier M, Eckstein F; for the OA Initiative investigators.
    MRI-based extended ordered values more efficiently differentiate cartilage loss in knees with and without joint space narrowing than region-specific approaches using MRI or radiography - data from the OA initiative.

    Osteoarthritis and Cartilage 19:689-699 (2011)

  • Cotofana S, Eckstein F, Wirth W, De Souza RB, Li X, Wyman B, Hellio-Le Graverand MP, Link T, Majumadar S
    In vivo measurs of cartilage deformation: patterns in healthy and osteoarthritic females knees using 3T MR imaging.
    European Radiology 21:1127-1135 (2011)

  • Mosher TJ, Zhang Z, Reddy R, Boudhar S, Milestone BN, Morrison WB, Kwoh CK, Eckstein F, Witschey WR, Borthakur A
    Knee articular cartilage damage in osteoarthritis: analysis of MR image biomarker reproducibility in ACRIN-PA 4001 multicenter trial.
    Radiology 258:832-842 (2011)


  • Inglis D, Wong AK, Eckstein F, Adachi JD, Beattie KA
    Multiplanar reconstruction recovers morphological cartilage assessment reproducibility from maloriented coronal MRI scans.
    Magnetic Resonance in Medicine 65:790-795 (2011)


  • Hudelmaier M, Wirth W, Wehr B, Kraus V, Wyman BT, Hellio Le Graverand MP, Eckstein F
    Femorotibial cartilage morphology: Reproducibility of different metrics and femoral regions, and sensitivity to change in disease.
    Cells Tissues Organs 192(5):340-50 (2010)


  • Wirth W, Nevitt M, Hellio Le Graverand MP, Benichou O, Dreher D, Davies RY, Lee J, Picha K, Gimona A, Maschek S, Hudelmaier M, Eckstein F; for the OAI investigators.
    Sensitivity to change of cartilage morphometry using coronal FLASH, sagittal DESS, and coronal MPR DESS protocols? comparative data from the osteoarthritis initiative (OAI).
    Osteoarthritis and Cartilage 18(4):547-54 (2010)


  • Wirth W, Benichou O, Kwoh CK, Guermazi A, Hunter D, Putz R, Eckstein F; for the OAI Investigators.
    Spatial patterns of cartilage loss in the medial femoral condyle in osteoarthritic knees: Data from the Osteoarthritis Initiative
    Osteoarthritis and Cartilage 63(3):574-81 (2010)


  • Buck RJ, Wyman BT, Le Graverand MP, Wirth W, Eckstein F; for the A9001140 Investigators.
    An efficient subset of morphological measures for articular cartilage in the healthy and diseased human knee.
    Magnetic Resonance in Medicine 63(3):680-90 (2010)


  • Eckstein F, Wyman BT, Buck RJ, Wirth W, Maschek S, Hudelmaier M, Hellio Le Graverand MP; 9001140 Study Group.
    Longitudinal quantitative MR imaging of cartilage morphology in the presence of gadopentetate dimeglumine (Gd-DTPA).
    Magnetic Resonance in Medicine 61(4):975-80 (2009)


  • Buck RJ, Wyman BT, Le Graverand MP, Hudelmaier, Wirth W, Eckstein F; for the A9001140 Investigators.
    Does the use of ordered values of subregional change in cartilage thickness improve teh detection of disease progression in longitudinal studies of osteoarthritis?
    Arthritis and Rheumatism 61:917-924 (2009)

  • Wirth W, Eckstein F
    A technique for regional analysis of femorotibial cartilage thickness based on quantitative magnetic resonance imaging.
    IEEE Transactions of Medical Imaging 27:737-44 (2008)


  • Eckstein F, Buck RJ, Burstein D, Charles HC, Crim J, Hudelmaier M, Hunter D, Hutchins G, Jackson C, Byers Kraus V, Lane NE, Link TM, Majumdar S, Mazzuca S,Prasad PV, Schnitzer TJ, Taljanovic MS, Vaz A, Wyman B, Hellio Le Graverand MP
    Precision of 3.0 Tesla quantitative magnetic resonance imaging of cartilage morphology in a multi center clinical trial.
    Annals of Rheumatic Diseases 67:1683-8 (2008).


  • Inglis D, Pui M, Ioannidis G, Beattie K, Boulos P, Adachi JD, Webber CE, Eckstein F
    Accuracy and test-retest precision of quantitative cartilage morphology on a 1.0 T peripheral magnetic resonance imaging system.
    Osteoarthritis and Cartilage. 15(1):110-5. (2007)


  • Eckstein F, Buck RJ, Wyman BT, Kotyk JJ, Le Graverand MP, Remmers AE, Evelhoch JL, Hudelmaier M, Charles HC
    Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentate dimeglumine (Gd-DTPA).
    Magnetic Resonance in Medicine 58(2):402-6 (2007)


  • Eckstein F, Ateshian G, Burgkart R, Burstein D, Cicuttini F, Dardzinski B, Gray M, Link TM, Majumdar S, Mosher T, Peterfy C, Totterman S, Waterton J, Winalski C, Felson D
    Proposal for a nomenclature for magnetic resonance imaging based measures of articular cartilage in osteoarthritis.
    Osteoarthritis and Cartilage 14 (10): 974-983 (2006)


  • Eckstein F, Hudelmaier M, Wirth W, Kiefer B, Jackson R, Yu J, Eaton C, Schneider E
    Double Echo Steady State (DESS) magnetic resonance imaging of knee articular cartilage at 3 Tesla ? a pilot study for the Osteoarthritis Initiative.
    Annals of Rheumatic Diseases 65 (4): 433-41 (2006)


  • Eckstein F, Buck R, Remmers A, Hudelmaier M, Wirth W, Krauss V, Charles C, Evelhoch J
    Accuracy and precision of quantitative assessment of cartilage status with 3.0 Tesla magnetic resonance imaging.
    Arthritis and Rheumatism 52(10): 3132-3136 (2005)


  • Graichen H, Al-Shamari D, Hinterwimmer S, von Eisenhart-Rothe R, Vogl T, Eckstein F
    Accuracy of quantitative MRI in the detection of ex vivo focal cartilage defects.
    Annals of Rheumatic Diseases 64: 1120-5 (2005)


  • McWalter EJ, Wirth W, Siebert M, von Eisenhart-Rothe RM, Hudelmaier M, Wilson DR, Eckstein F
    Use of novel interactive input devices for segmentation of articular cartilage from magnetic resonance images.
    Osteoarthritis and Cartilage 13(1):48-53 (2005)


  • Graichen H, v. Eisenhart-Rothe R, Vogl T, Englmeier KH, Eckstein F
    Quantitative assessment of cartilage status in osteoarthritis by quantitative magnetic resonance imaging: technical validation for use in analysis of cartilage volume and further morphologic parameters.
    Arthritis and Rheumatism 50: 811?816 (2004)


  • Graichen H, Jakob J, v. Eisenhart-Rothe R, Englmeier KH, Reiser M, Eckstein F
    Validation of cartilage thickness measurements in the human shoulder with quantitative magnetic resonance imaging (qMRI)
    Osteoarthritis and Cartilage 11: 475-482 (2003)


  • Glaser C, Burgkart R, Kutschera A, Englmeier KH, Reiser M, Eckstein F
    Femoro-tibial cartilage metrics from coronal MR image data: technique, test-retest reproducibility, and findings in OA.
    Magnetic Resonance in Medicine 50: 1229-1236 (2003)


  • Hohe J, Ateshian G, Reiser M, Englmeier KH, Eckstein F
    Surface size, curvature analysis, and quantitative assessment of knee joint incongruity with MR imaging in vivo.
    Magnetic Resonance in Medicine 47: 554-561 (2002)


  • Hohe J, Faber S, Mühlbauer R, Reiser M, Englmeier KH, Eckstein F
    Three-dimensional analysis and visualization of regonal MR signal intensity distribution of articular cartilage.
    Medical Engineering and Physics 24: 219-227 (2002)


  • Eckstein F, Heudorfer L, Faber S, Burgkart R, Englmeier KH, Reiser M
    Long-term and resegmentation precision of quantitative cartilage MR imaging (qMRI)
    Osteoarthritis and Cartilage 10: 922 - 927 (2002)


  • Glaser C, Faber S, Eckstein F, Fischer H, Springer V, Heudorfer L, Stammberger T, Englmeier K, Reiser M
    Optimization and validation of a rapid high-resolution T1-w 3D Flash waterexcitation MR sequence for the quantitative assessment of articular cartilage volume and thickness.
    Magnetic Resonance Imaging 19: 177 -185 (2001)


  • Burgkart R, Glaser C, Hyhlik-Dürr A, Englmeier KH, Reiser M, Eckstein F
    MRI-based assessment of cartilage loss in severe osteoarthritis? Accuracy, precision, and diagnostic value.
    Arthritis and Rheumatism 44: 2072 - 2077 (2001)


  • Eckstein F, Stammberger T, Priebsch J, Englmeier KH, Reiser M
    Effect of gradient and section orientation on quantitative analyses of knee joint cartilage.
    Journal of Magnetic Resonance Imaging 11: 161 -167 (2000)


  • Hyhlik-Dürr A, Faber S, Burgkart R, Stammberger T, Maag KP, Englmeier KH, Reiser M, Eckstein F
    Precision of tibial cartilage morphometry with a coronal water-excitation MR-sequence.
    European Radiology 10: 297-303 (2000)


  • Stammberger T, Hohe J, Englmeier KH, Reiser M, Eckstein F
    Elastic registration of 3D cartilage surfaces from MR image data for detecting local changes of the cartilage thickness.
    Magnetic Resonance in Medicine 44: 592-601 (2000)


  • Hohe J, Faber S, Stammberger T, Englmeier KH, Reiser M, Eckstein F
    A technique for 3D in vivo quantification of proton density and magnetization transfer coefficients of knee joint cartilage.
    Osteoarthritis and Cartilage 8:426-433 (2000)


  • Stammberger T, Eckstein F, Englmeier KH, Reiser M
    Determination of 3D cartilage thickness data from MR imaging - computational method and reproducibility in the living.
    Magnetic Resonance in Medicine 41: 529 - 536 (1999)


  • Stammberger T, Eckstein F, Michaelis M, Englmeier KH, Reiser M
    Interobserver reproducibility of quantitative cartilage measurements: comparsion between B-spline snakes and manual segmentation.
    Magnetic Resonance Imaging 17: 1033 -1042 (1999)


  • Eckstein F, Westhoff J, Sittek H, Maag KP, Haubner M, Faber S, Englmeier KH, Reiser M
    In vivo reproducibility of three-dimensional cartilage volume and thickness measurements with magnetic resonance imaging.
    American Journal of Radiology 170: 593 - 597 (1998)


  • Herberhold C, Stammberger T, Faber S, Putz R, Englmeier KH, Reiser M, Eckstein F
    An MR-based technique for quantifying the deformation of articular cartilage during mechanical loading in an intact cadaver joint.
    Magnetic Resonance in Medicine 39: 843 - 850 (1998)


  • Eckstein F, Schnier M, Haubner M, Priebsch J, Glaser C, Englmeier KH, Reiser M
    Accuracy of three-dimensional knee joint cartilage volume and thickness measurements with MRI.
    Clinical Orthopaedics and Related Research 352: 137 - 148 (1998)


  • Stammberger T, Herberhold C, Faber S, Englmeier KH, Reiser M, Eckstein F
    A method for quantifying time-dependent changes in MR signal intensity of articular cartilage as a function of tissue deformation in intact joints.
    Medical Engineering and Physics 20: 741-749 (1998)


  • Eckstein F, Adam C, Sittek H, Becker C, Milz S, Schulte E, Reiser M, Putz R
    Non-invasive determination of cartilage thickness throughout joint surfaces using magnetic resonance imaging.
    Journal of Biomechanics 30: 285 - 289 (1997)


  • Englmeier KH, Haubner M, Lösch A, Eckstein F, Seemann MR, van Eimeren W, Reiser M
    Hybrid rendering of multidimensional image data.
    Methods of Information in Medicine 36: 1 - 10 (1997)


  • Lösch A, Eckstein F, Haubner M, Englmeier KH
    A non-invasive technique for 3-dimensional assessment of articular cartilage thickness based on MRI - Part I: development of a computational method.
    Magnetic Resonance Imaging 15: 795 - 804 (1997)


  • Haubner M, Eckstein F, Lösch A, Schnier M, Sittek H, Becker C, Kolem H, Reiser M, Englmeier KH
    A non-invasive technique for 3-dimensional assessment of articular cartilage thickness based on MRI -Part II: Validation with CT arthrography.
    Magnetic Resonance Imaging 15: 805 - 813 (1997)


  • Tieschky M, Faber S, Haubner M, Kolem H, Schulte E, Englmeier KH, Reiser M, Eckstein F
    Repeatability of patellar cartilage thickness patterns in the living, using a fat-suppressed MRI sequence with short acquisition time and 3D data processing.
    Journal of Orthopaedic Research 15: 808 - 813 (1997)


  • Eckstein F, Sittek H, Gavazzeni A, Schulte E, Kiefer B, Milz S, Reiser M, Putz R
    Magnetic resonance chondro-crassometry (MR-CCM): a method for accurate determination of articular cartilage thickness?
    Magnetic Resonance in Medicine 35: 89 - 96 (1996)


  • Sittek H, Eckstein F, Gavazzeni A, Milz S, Kiefer B, Schulte E, Reiser M
    Assessment of normal patellar cartilage volume and thickness using MRI: an analysis of currently available pulse sequences.
    Skeletal Radiology 25: 55 - 62 (1996)


  • Eckstein F, Merz B, Sittek H, Kolem H, Reiser M, Putz R
    Geometry-to-pressure relationship in the human elbow joint - a qualitative analysis using MRI and finite elements.
    European Journal of Anatomy 1: 23 - 30 (1996)


  • Eckstein F, Gavazzeni A, Sittek H, Haubner M, Lösch A, Milz S, Englmeier KH, Schulte E, Putz R, Reiser M
    Determination of knee-joint cartilage thickness using three-dimensional magnetic resonance chondro-crassometry (3D MR-CCM).
    Magnetic Resonance in Medicine 36: 256 - 265 (1996)


  • Münsterer O, Eckstein F, Hahn D, Putz R
    Computer-aided 3D assessment of knee joint cartilage with magnetic resonance imaging.
    Clinical Biomechanics 11: 260 - 266 (1996)


  • Eckstein F, Sittek H, Milz S, Schulte E, Kiefer B, Reiser M, Putz R
    The potential of magnetic resonance imaging (MRI) for quantifying articular cartilage thickness - a methodological study.
    Clinical Biomechanics 10: 434 - 440 (1995)


  • Eckstein F, Sittek H, Milz S, Putz R, Reiser M
    The morphology of articular cartilage assessed by magnetic resonance imaging (MRI) - Reproducibility and anatomical correlation.
    Surgical and Radiologic Anatomy 16: 429 - 438 (1994)

    • Application


      Wirth W, Maschek S, Beringer P, Eckstein F

      Subregional laminar cartilage MR spin-spin relaxation times (T2) in osteoarthritic knees with and without medial femorotibial cartilage loss - data from the Osteoarthritis Initiative (OAI).

      Osteoarthritis and Cartilage 2017 Mar 27. (Epub ahead of print)


      Boeth H, MacMahon A, Eckstein F, Diederichs G, Schlausch A, Wirth W, Duda GN

      MRI findings of knee abnormalities in adolescent and adult volleyball players.

      Journal of Experimental Orthopaedics 4(1):6 (2017)


      Culvenor AG, Wirth W, Maschek S, Boeth H, Diederichs G, Duda G, Eckstein F

      Longitudinal change in patellofemoral cartilage thickness, cartilage T2 relaxation times, and subchondral bone plate area in adolescent vs mature athletes.

      European Journal of Radiology 92:24-29 (2017)


      Moyer R, Wirth W, Eckstein F

      Longitudinal changes in MRI-based measures of femorotibial cartilage thickness as a function of alignment and obesity data from the OAI.

      Arthritis Care and Research (Hoboken) [Epub ahead of print]


      Kwee RM, Wirth W, Hafezi-Nejad N, Zikria BA, Guermazi A, Demehri S

      Role of physical activity in cartilage damage progression of subjects with baseline full-thickness cartilage defects in medial tibiofemoral compartment: data from the Osteoarthritis Initiative.

      Osteoarthritis and Cartilage 24(11):1898-1904 (2016)


      Roemer FW, Aydemir A, Lohmander S, Crema MD, Marra MD, Muurahainen N, Felson DT, Eckstein F, Guermazi A

      Structural effects of sprifermin in knee osteoarthritis: a post-hoc analysis on cartilage and non-cartilaginous tissue alterations in a randomized controlled trial.

      BMC Musculoskeletal Disorders 17:267 (2016)


      Roemer FW, Kwoh CK, Hannon MJ, Hunter DJ, Eckstein F, Grago J, Boudreau RM, Englund M, Guermazi A
      Partial meniscectomy is associated with increased risk of  incident radiographic osteoarthritis and worsening cartilage damage in the following year.

      European Radiology 27(1):404-413 (2016)


      van der Woude JA, van Heerwaarden RJ, Spruijt S, Eckstein F, Maschek S, van Roermund PM, Custers RJ, van Spil WE, Mastbergen SC, Lafeber FP

      Six weeks of continuous joint distraction appears sufficient for clinical benefit and cartilaginous tissue repair in the treatment of knee osteoarthritis.

      Knee 23(5):785-791(2016)


      Moyer R, Wirth W, Duryea J, Eckstein F

      Anatomical alignment, but not goniometry, predicts femorotibial cartilage loss as well as mechanical alignment:

      data from the Osteoarthritis Initiative.

      Osteoarthritis and Cartilage 24(2):254-261 (2016) 

       

      Eckstein F, Boudreau R, Wang Z, Hannon MJ, Duryea J, Wirth W, Cotofana S, Guermazi A, Roemer F, Nevitt M, John MR, Ladel C, Sharma L, Hunter DJ, Kwoh CK; OAI Investigators

      Comparison of radiographic joint space width and magnetic resonance imaging for prediction of knee replacement: A longitudinal case-control study from the Osteoarthritis Initiative.

      European Radiology 26(6):1942-1951(2016)

      Eckstein F, Collins JE, Nevitt MC, Lynch JA, Kraus V, Katz JN, Losina E, Wirth W, Guermazi A, Roemer FW, Hunter DJ; FNIH OA Biomarkers Consortium

      Cartilage thickness change as an imaging biomarker of knee osteoarthritis progression - data from the OA biomarkers consortium.

      Arthritis and Rheumatology 67:3184-3189 (2015) 

       

      Ried JS, Flechsenhar K, Bartnik E, Crowther D, Dietrich A, Eckstein F

      Sample size calculations for detecting DMOAD effects on knee replacement in clinical trials - data from the Osteoarthritis Initiative.

      Arthritis and Rheumatology 67: 3174-3183 (2015)

       

      Moyer R, Wirth W, Eckstein F

      Sensitivity of different measures of frontal plane alignment to medial and lateral joint space narrowing: from the

      Osteoarthritis Initiative.

      Seminars in  Arthritis and Rheumatism 45:268-274 (2015)

       

      Eckstein F, Wirth W, Guermazi A, Maschek S, Aydemir A

      Intra-articular sprifermin not only increases cartilage thickness, but also reduces cartilage loss - location-independent post hoc analysis using MR imaging
      Arthritis and Rheumatology 67:2916-2922 (2015)

      Hitzl W, Wirth W, Maschek S, Cotofana S, Nevitt M, John MR, Ladel C, Eckstein F
      Greater lateral femorotibial cartilage loss in osteoarthritis initiative participants with incident knee replacement: A prospective cohort study.
      Arthritis Care and Research 67:1481-1486 (2015) 

      Roemer FW, Kwoh CK, Hannon MJ, Hunter DJ, Eckstein F, Wang Z, Boudreau RM, John MR, Nevitt MC, Guermazi A
      Can structural joint damage measured with MR imaging be used to predict knee replacement in the following year?
      Radiology 274:810-820 (2015)

      Chang AH, Moisio KC, Chmiel JS, Eckstein F, Guermazi A, Prasad PV, Zhang Y, Almagor O, Belisle L, Hayes K, Sharma L. External knee adduction and flexion moments during gait and medial tibiofemoral disease progression in knee osteoarthritis.
      Osteoarthritis and Cartilage 23:1099-1106 (2015)

      Moroder P, Runer A, Kraemer M, Fierlbeck J, Niederberger A, Cotofana S, Vasvari I, Hettegger B, Tauber M, Hurschler C, Resch H

      Influence of defect size and localization on the engagement of reverse hill-sachs lesions.
      American Journal of Sports Medicine 43:542-548 (2015)

      Eckstein F, Wirth W, Lohmander LS, Hudelmaier MI, Frobell RB

      Five-year follow-up of knee joint cartilage thickness changes after acute anterior cruciate ligament rupture.
      Arthritis and Rheumatology 67:152-161(2015)

      Maschek S, Wirth W, Ladel C, Hellio Le Graverand M.-P., Eckstein FRates and sensitivity of knee cartilage thickness loss in specific central reading radiographic strata from the Osteoarthritis Initiative.
      Osteoarthritis and Cartilage 22: 1550-1553 (2014)

      Cotofana S, Benichou O, Hitzl W, Wirth W, Eckstein F
      Is loss in femorotibial cartilage thickness related to severity of contra-lateral radiographic knee osteoarthritis? Longitudinal data from the Osteoarthritis Initiative.
      Osteoarthritis and Cartilage 22:2059-2066 (2014)

      Eckstein F, Wirth W, Lohmander LS, Hudelmaier MI, Frobell RB
      Five-year follow-up of knee joint cartilage thickness changes after acute anterior cruciate ligament rupture.
      Arthritis and Rheumatology 67:152-161 (2014)

      Eckstein F, Boudreau RM, Wang Z, Hannon MJ, Wirth W, Cotofana S, Guermazi A, Roemer F, Nevitt M, John MR, Ladel C, Sharma L, Hunter DJ, Kwoh CK; for the OAI investigators

      Trajectory of cartilage loss within 4 years of knee replacement - a nested case-control study from the Osteoarthritis Initiative.

      Osteoarthritis and Cartilage 22: 1542-1549 (2014)


      Lohmander LS, Hellot S, Dreher D, Krantz EF, Kruger DS, Guermazi A, Eckstein F

      Intra-articular sprifermin (recombinant human fibroblast growth factor 18) in knee osteoarthritis: randomized, double-blind, placebo-controlled trial.
      Arthritis and Rheumatology 66:1820-1831 (2014)

      Eckstein F, Boeth H, Diederichs G, Wirth W, Hudelmaier M, Cotofana S, Hofmann-Amtenbrink M, Duda G Longitudinal change in femorotibial cartilage thickness and subchondral bone plate area in male and female adolescent vs. mature athletes.
      Annals of Anatomy 196:150-157 (2014)

      Doria AS, Zhang N, Lundin B, Hilliard P, Man C, Weiss R, Detzler G, Blanchette V, Moineddin R, Eckstein F, Sussman MS

      Quantitative versus semiquantitative MR imaging of cartilage in blood-induced arthritic ankles: preliminary findings.
      Pediatric Radiology 44:576-586 (2014)

      Wirth W, Nevitt M, Le Graverand MP, Lynch J, Maschek S, Hudelmaier M, Eckstein F; for the OA Initiative Investigators Group
      Lateral and medial joint space narrowing predict subsequent cartilage loss in the narrowed, but not in the non-narrowed femorotibial compartment - data from the Osteoarthritis Initiative
      Osteoarthritis and Cartilage 22:63-70 (2014)

      Cotofana S, Buck R, Dreher D, Wirth W, Roemer F, Duryea J, Nevitt M, Eckstein F; for the Osteoarthritis Initiative Investigators
      Longitudinal (1-year) change in cartilage thickness in knees with early knee osteoarthritis: A within-person between-knee comparison-data from the OAI.
      Arthritis Care and Research 66:636-641 (2014)
       

      Wiegant K, van Roermund PM, Intema F, Cotofana S, Eckstein F, Mastbergen SC, Lafeber FP
      Sustained clinical and structural benefit after joint distraction in the treatment of severe knee osteoarthritis.
      Osteoarthritis and Cartilage 21:1660-1667 (2013)
       

      Cotofana S, Wyman BT, Benichou O, Dreher D, Nevitt M, Gardiner J, Wirth W, Hitzl W, Kwoh CK, Eckstein F, Frobell RB, for the OAI Investigators

      Group relationship between knee pain and the presence, location, size and phenotype of femorotibial denuded areas of subchondral bone as visualized by MRI
      Osteoarthritis and Cartilage 21:1214-1222 (2013)

      Crema MD, Hunter DJ, Burstein D, Roemer FW, Li L, Eckstein F, Krishnan N, Hellio Le-Graverand MP, Guermazi A
      Association of changes in delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) with changes in cartilage thickness in the medial tibiofemoral compartment of the knee: a 2 year follow-up study using 3.0 T MRI.
      Annals of the Rheumatic Diseases 73:1935-1941 (2014)

      Eckstein F, Kwoh CK, Boudreau RM, Wang Z, Hannon MJ, Cotofana S, Hudelmaier M, Wirth W, Guermazi A, Nevitt M, John M, Hunter D; for the OAI Investigators.
      Quantitative MRI measures of cartilage predict knee replacement: a case-control study from the Osteoarthritis Initiative.
      Annals of Rheumatic Diseases 72:707-714 (2013)

      Kraus VB, Feng S, Wang S, White S, Ainslie M, Graverand MP, Brett A, Eckstein F, Hunter DJ, Lane NE, Taljanovic MS, Schnitzer T, Charles HC
      S
      ubchondral bone trabecular integrity predicts and changes concurrently with radiographic and magnetic resonance imaging-determined knee osteoarthritis progression.
      Arthritis and Rheumatism 65:1812-1821(2013)


      Buck RJ, Wirth W, Dreher D, Nevitt M, Eckstein F

      Frequency and spatial distribution of cartilage thickness change in knee osteoarthritis and its relation to clinical and radiographic covariates - data from the Osteoarthritis Initiative

      Osteoarthritis and Cartilage 21:102-109 (2013)